Graduate Program


Jianguo Gu, Ph.D.,
Department of Anesthesiology

 An overview of current and future research interests


Jianguo Gu, MB, PhD, Professor, Department of Anesthesiology, University of Cincinnati College of Medicine, Editor-in-Chief, Molecular Pain,

Dr. Gu's research has been 1) to study cellular, subcellular and molecular mechanisms by which sensory signals including pain are initiated, conducted, transmitted, and modulated at different sites along sensory pathways, 2) to investigate how these mechanisms are altered under pathological conditions to contribute to pathological pain states including chronic inflammatory pain, neuropathic pain, and central pain, and 3) to explore whether, based on these mechanisms, pharmacological interventions can be developed to effectively treat/manage pathological pain. 


Specifically, Dr. Gu's  lab has been studying temperature-sensing molecules for a number of years. His lab is currently focusing on transient receptor potential M8 channels (TRPM8) to study the roles of these channels in encoding cold stimuli at primary afferent nerve endings and in mediating physiological and pathological pain induced by cold temperatures. The long-term goal of this research project is to develop specific TRPM8 receptor antagonists for clinical treatment of cold pain in patients. Dr. Gu's lab is also interested in molecules for mechanical sensory system. One line of research is to explore the role of ATP P2X receptors in transmitting mechanical stimulation from peripheral tissues to the CNS region the spinal cord dorsal horn. In addition to peripheral sensory molecules, Dr. Gu's lab has been studying central mechanisms involved in modulation of sensory transmission in the spinal cord dorsal horn. One research project is to study receptor mechanisms of sensory plasticity and hyperactivity in nociceptive processing regions in the spinal cord dorsal horn. 

Representative Publications


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