FacultyJianguo Gu, Ph.D.,
Department of Anesthesiology
An overview of current and future research interests
Jianguo Gu, MB, PhD, Professor, Department of Anesthesiology, University of Cincinnati College of Medicine, Editor-in-Chief, Molecular Pain, www.molecularpain.com
Specifically, Dr. Gu's lab has been studying temperature-sensing molecules for a number of years. His lab is currently focusing on transient receptor potential M8 channels (TRPM8) to study the roles of these channels in encoding cold stimuli at primary afferent nerve endings and in mediating physiological and pathological pain induced by cold temperatures. The long-term goal of this research project is to develop specific TRPM8 receptor antagonists for clinical treatment of cold pain in patients. Dr. Gu's lab is also interested in molecules for mechanical sensory system. One line of research is to explore the role of ATP P2X receptors in transmitting mechanical stimulation from peripheral tissues to the CNS region the spinal cord dorsal horn. In addition to peripheral sensory molecules, Dr. Gu's lab has been studying central mechanisms involved in modulation of sensory transmission in the spinal cord dorsal horn. One research project is to study receptor mechanisms of sensory plasticity and hyperactivity in nociceptive processing regions in the spinal cord dorsal horn.